Scientific References
Centers for Disease Control and Prevention. Morbidity and Mortality Weekly Report. March 10, 2017. Vol. 66. No. 9.

Sawitzke AD, Shi H, Finco MF, Dunlop DD, Bingham CO 3rd, Harris CL, Singer NG, Bradley JD, Silver D, Jackson CG, Lane NE, Oddis CV, Wolfe F, Lisse J, Furst DE, Reda DJ, Moskowitz RW, Williams HJ, Clegg DO. The effect of glucosamine and/or chondroitin sulfate on the progression of knee OA: a report from the glucosamine/chondroitin arth intervention trial. Arth Rheum. 2008 Oct;58 (10):3183-91. doi: 10.1002/art.23973.

Ian J. Wallace, Steven Worthington, David T. Felson, Robert D. Jurmain, Kimberly T. Wren, Heli Maijanen, Robert J. Woods, and Daniel E. Lieberman. Knee OA has doubled in prevalence since the mid-20th century. Anthropology. August 14, 2017. doi.org/10.1073/

Tamer TM. Hyaluronan and synovial joint: function, distribution and healing. Interdiscip Toxicol. 2013;6(3):111-125. doi:10.2478/intox-2013-0019

Necas, J., Bartosikova, L., Brauner, P., & Kolar, J. (2008). Hyaluronic acid (hyaluronan): A review. Veterinarni Medicina, 53(8), 397–411. doi.org/10.17221

Ingram KR, Wann AK, Angel CK, Coleman PJ, Levick JR. Cyclic movement stimulates hyaluronan secretion into the synovial cavity of rabbit joints. J Physiol. 2008;586(6):1715-1729. doi:10.1113/jphysiol.2007.146753

J R Levick. Physiology, Basic Medical Sciences, St. George’s Hospital Medical School, Hyaluronan, the guardian of joints. Physiology News Magazine. [2007]. Issue 67. doi.org/10.36866/pn.67.18

Oe, M., Tashiro, T., Yoshida, H. et al. Oral hyaluronan relieves knee pain: a review. Nutrition Journal 15, 11 (2015). doi.org/10.1186/s12937-016-0128-2

Jung H. Hyaluronidase: An overview of its properties, applications, and side effects. Arch Plast Surg. 2020;47(4):297-300. doi:10.5999/aps.2020.00752

Temple-Wong MM, Ren S, Quach P, et al. Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration. Arth Res Ther. Published 2016 Jan 21. doi:10.1186/s13075-016-0922-4

Nicholls MA, Fierlinger A, Niazi F, Bhandari M. The Disease-Modifying Effects of Hyaluronan in the OA Disease State. Clin Med Insights Arth Musculoskelet Disord. 2017. doi:10.1177/1179544117723611

Tashiro T, Seino S, Sato T, Matsuoka R, Masuda Y, Fukui N. Oral administration of polymer hyaluronic acid alleviates symptoms of knee OA: a double-blind, placebo-controlled study over a 12-month period. Scientific World Journal. 2012. doi: 10.1100/2012/167928.

Möller I, Martinez-Puig D, Chetrit C. Oral administration of a natural extract rich in hyaluronic acid for the treatment of knee OA with synovitis: a retrospective cohort study. Clinical Nutrition Supplements 2009.

Douglas S Kalman, Maria Heimer, Anita Valdeon, Howard Schwartz and Eric Sheldon. Effect of a natural extract of chicken combs with a high content of hyaluronic acid on pain relief and quality of life in subjects with knee OA: a pilot randomized double-blind placebo-controlled trial. Nutrition Journal 2008

Martinez-Puig D, Möller I, Fernández C, Chetrit C. Efficacy of oral administration of yoghurt supplemented with a preparation containing hyaluronic acid (Mobilee™) in adults with mild joint discomfort: a randomized, double-blind, placebo controlled intervention study. Mediterranean Journal of Nutrition and Metabolism 2013;6:63–68.